A Review on Recent One Pot Multi-Component Synthesis and Biological Properties of a Class of New Class of Chromenes, Coumarines, Chromeno-Pyrimidines, Pyrido-Pyrimidine and Quinazoline Heterocycles
Sourav Dey
Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
Koushik Chakraborty
Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
Pranab Ghosh *
Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
*Author to whom correspondence should be addressed.
Abstract
The chromenes, coumarines, pyrido-pyrimidine and quinazoline cores possesses a vast number of biological activities such as anticancer, anti-malarial, anti-microbial, anti-fungal, anti-tubercular activities and the conventional classical synthetic methods have harsh conditions having multistep process. Currently, researchers are in search of new methodology to eliminate the use of chemicals, solvents and catalysts, which are hazardous to human health as well as to environment. This review provides a concise overview of new dimensions of one pot multi-component synthetic approaches in designing chromenes, coumarines, pyrido-pyrimidine and quinazoline scaffolds. This review will give more scientific ideas to synthesis a variety of heterocyclic moieties in a new synthetic way following the one-pot multi-component method.
Keywords: Chromenes, Coumarines, Pyrido-pyrimidines and Quinazolines, 1,4-dihydropyridines, tetrazoloquinazolinones, One-pot reactions, Multicomponent synthesis