https://journalajacr.com/index.php/AJACR/issue/feed Asian Journal of Applied Chemistry Research 2024-01-27T06:31:32+00:00 Asian Journal of Applied Chemistry Research contact@journalajacr.com Open Journal Systems <p><strong>Asian Journal of Applied Chemistry Research (ISSN: 2582-0273)</strong> aims to publish high-quality papers (<a href="https://journalajacr.com/index.php/AJACR/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of 'chemistry and its application'. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> https://journalajacr.com/index.php/AJACR/article/view/272 Accurate Estimation of Some Pharmaceutical Compounds Using HPLC Technology 2023-11-18T12:33:03+00:00 Qasim Mezban Salih kgamli@uowasit.edu.iq <p>For the assessment of different chemical components in pharmaceutical and biological&nbsp;samples, High Performance Liquid Chromatography (HPLC) can be defined as&nbsp;a commonly utilized&nbsp;analytical method&nbsp;in pharmaceutical samples. HPLC offers high sensitivity, specificity, and accuracy, making it a preferred method for the analysis of complex samples. In this technique, the sample is prepared by extracting, purifying, and concentrating the target analyte from the matrix. Mobile and stationary phases&nbsp;are after that&nbsp;used in chromatographic separation of the prepared&nbsp;sample. Several detectors, including fluorescence, UV-vis,&nbsp;and mass spectrometry, are used to identify and measure the eluted compounds. HPLC is capable of estimating a wide range of elements, including small molecules, peptides, and proteins, making it an essential tool in pharmaceutical research and development. The theoretical plates, peak tailing,&nbsp;and % assay have not been significantly impacted by the deliberate alterations made to the method. This implies that the existing technique&nbsp;is robust. The low values of LOQ and LOD&nbsp;show how sensitive the suggested approach is.&nbsp;The current research&nbsp;used a standard drug&nbsp;solution with six replicates to examine the system suitability parameters. It was discovered that the computed parameters fell under the acceptable criteria. The theoretical plate count, tailing factor,&nbsp;and HETP parameters are all within acceptable ranges. The&nbsp;results of this work are compared&nbsp;with those of earlier research. Upon analyzing the chart, it can be inferred that the proposed method presents certain benefits. The investigation employed a Kromasil C18 column. The obtained retention time is comparatively lower than that of all other methodologies. The maximum quantifiable threshold is 600 μg/mL, surpassing or equating all of the aforementioned techniques. The duration of the execution is also minimal. Therefore, the author draws the conclusion that the HPLC method proposed exhibits sensitivity and reproducibility in analysis of etodolac and thiocolchicoside in combined tablet dosage form, while also requiring a short analysis time.</p> 2023-11-18T00:00:00+00:00 Copyright (c) 2023 Salih; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajacr.com/index.php/AJACR/article/view/273 Impact of Preferred Orientation and Strain on Olopetadine HCL by Using XRD Technique 2023-11-25T08:03:37+00:00 Shivaji Jadhav shiva29us@yahoo.com Amit Jadkar Namdev Mote Shridhar Tamse Amit Gosar Dileep Mahajan <p>This research article investigates the impact on the crystal structure of Olopatadine HCl using an X-ray diffractometer. During the stability study, the diffractogram obtained shows a significant shift in 2ϴ, which can be attributed to the presence of strain and preferred orientation within the crystal lattice. The study reveals that the strain is caused by lattice defects and may be due to moisture, while the preferred orientation can be attributed to the method of preparation adopted. The results indicate that the crystal structure of Olopatadine HCl is complex and requires further investigation to fully understand its properties. The findings of this study could be used to optimise the synthesis protocol and improve the material properties for various applications.</p> 2023-11-25T00:00:00+00:00 Copyright (c) 2023 Jadhav et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajacr.com/index.php/AJACR/article/view/274 Development of a Robust Method for Screening PDE-5 Inhibitor Additives in Dietary Supplements Using UPLC-MS/MS 2023-12-09T08:00:53+00:00 Hua Wang wangh@yctu.edu.cn <p>A novel ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method was developed to detect the illegal additive of phosphodiesterase type 5 (PDE-5) inhibitors in dietary supplements. With the optimized chromatographic program, vardenafil, sildenafil, and tadalafil were separated within 5 minutes. The MS<sup>1</sup>, MS<sup>2</sup>, and retention time of PDE-5 inhibitors were acquired simultaneously within the information dependent acquisition mass spectrometry mode. Quantification was achieved via the quantity ion current chromatogram that was extracted from the total ion current. The linear range of vardenafil and sildenafil was 0.5-48 mg/L while the range of tadalafil was 0.3-36 mg/L. The correlation coefficients of the calibration curves of three PDE-5 inhibitors were all greater than 99.9%. At three concentration levels, the RSD values of the five repeat tests were all better than 1.30%. Sildenafil was detected in one dietary supplement. The comprehensive method of this study is reliable and may be a powerful tool for routine PDE-5 inhibitor screening and determination.</p> 2023-12-09T00:00:00+00:00 Copyright (c) 2023 2023 Wang; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajacr.com/index.php/AJACR/article/view/275 FTIR and XRD Characterization of the Cements Available in Commercial Market of Nepal 2023-12-22T10:55:55+00:00 Gaurab Baral Anant Babu Marahatta anant.marahatta@kathford.edu.np <p>In the engineering material characterizations and analytical domains where the specific physicochemical properties of the materials are probed through various sophisticated instrumental tools and techniques, the XRD and FTIR spectroscopy stand as the standalone applications as the former discloses the crystallographic structure, crystallite/grain sizes, and the chemical compositions of the specific materials nondestructively while the latter reveals details about the IR active vibrations modes of each covalent bond of their chemical constituents. In the present studies, we employ both of these techniques, and characterize the specifically selected variable manufactured ready-to-use dry OPC type cements available in the commercial markets of Nepal. The former technique derived the specific 2\(\theta\) value deterministic for identifying the closely packed interatomic layers with the significant levels of CaCO<sub>3, </sub>Ca(OH)<sub>2</sub>, and arsenic As<sup>5+</sup> based AsO<sub>4</sub><sup>3</sup><sup>-</sup> unit bearing crystalline phases in each samples. The calculated crystallite sizes of them are found as equal as that reported for the calcite based OPC cements, and are directly adopted to depict their utmost intermixing propensities with the carbon dust and hence, act as the most potential evidence of unlocking the possibility of inventing cement-carbon composites based supercapacitors and conductive devices, and of speculating their distinguishable hydration rates and setting times. And, the latter technique produced intense IR active bands in the designated wave number regions are used to confirm their silicate (SiO<sub>4</sub><sup>2</sup><sup>-</sup>) tetrahedra, amorphous CaCO<sub>3</sub> phases &amp; the CO<sub>3</sub><sup>2</sup><sup>-</sup>unit holding chemical constituents, 2CaO.SiO<sub>2</sub> and 3CaO.SiO<sub>2</sub> type chemical compounds explicitly. The presence of diffused type IR bands specific to the Al<sub>2</sub>O<sub>3</sub> based chemical compounds signified that all of them contains significant levels of the alumina based hardening elements, but the complete absence of the peak typical to the Mg-O signified that none of them contains magnesia. The similar analyses of the IR bands further reveal that none of them possesses heavy and active type CaCO<sub>3</sub>, but have trace amounts of the AsO<sub>4</sub><sup>3</sup><sup>-</sup> based chemical compounds as predicted by the XRD. The intensive peak area and the depth intensity studies of the designated IR bands speculate the dissimilar quantitative proportions and percentage compositions of these chemical constituents in them. The authors believe that the general results presented herewith illuminate the fundamental chemical constituents to be incorporated compulsorily into the OPC type cements so that they function normally and exhibit good cementitious abilities.</p> 2023-12-22T00:00:00+00:00 Copyright (c) 2023 Baral and Marahatta; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajacr.com/index.php/AJACR/article/view/276 Cellulose Nanocrystals Isolated from Bean Seed Hulls: Acetylation and Characterization 2024-01-27T06:31:32+00:00 Ebele Joy Morah ej.morah@unizik.edu.ng David Okechukwu Okeke Ozioma Juliana Anekwe-Nwekeaku Chidinma Malinda Muobike Uchechukwu Joachin Ezenyeaka <p>Bean seed hulls is an agro-waste with abundant content of lignocellulosic materials but are being wasted due to its underutilization. Cellulose nanocrystals (CNCs) were successfully extracted from bean seed hulls using alkali treatment, bleaching and sulphuric acid hydrolysis. Cellulose triacetate (CTA) was obtained from CNCs by acetylation using acetic anhydride with sulphuric acid as catalyst. CNCs is neutral pH whereas CTA is slightly acidic. CNCs was sparingly soluble in ethanol but CTA was completely soluble in ethanol. CTA has a higher melting point than CNCs. The density of both CNCs and CTA is approximately equal to the density of water. SEM analysis revealed that CNCs is irregular and fragmented in nature and has both more large surface area and porosity than CTA. FTIR analysis showed the presence of the dominant functional groups such as O-H stretch, N-H stretch, C-H stretch, C-O stretch and C-N stretch in both CNCs and CTA. GC-MS analysis revealed the presence of the prevalent organic compounds such as alkanes, alcohols, phenols, alkanones, phthalates, carboxylic acids, esters and triterpene in both CNCs and CTA. Therefore, the isolation of CNCs from bean seed hulls suggests great efficacy to recover the under-utilized agro-wastes thereby preventing air pollution.</p> 2023-12-30T00:00:00+00:00 Copyright (c) 2023 Morah et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.