Main Article Content
Metal complexes of Cu(II), Co(II) and Cd(II) have been synthesized using two new Schiff base ligands, N,N'-bis(4-chlorobenzylidene)ethane-1,2-diamine (L1) and N,N'-bis(3-nitrobenzylidene) ethane-1,2-diamine (L2). The Schiff bases were prepared from the condensation reaction of ethylenediamine with benzaldehyde derivatives (4-chlorobenzaldehyde and 3-nitrobenzaldehyde). The complexes have been characterized by elemental analysis, conductivity measurements, UV-visible, FT-IR and magnetic susceptibility measurements. The magnetic susceptibility measurements and UV-visible spectral data revealed that the geometry of Cu(II) and Co(II) complexes are square planar, whereas the geometry of Cd(II) complex is tetrahedral. The molar conductance data showed that the complexes are non-electrolytic in nature. The complexes were screened for antibacterial activities against four human pathogenic bacteria viz. Escherichia coli, Shigella boydii, Bacillus cereus and Staphylococcus aureus. The results indicate that Cd(II) complex of ligand (L1) has higher antibacterial activity compared to the free ligands, but less than the standard drug, kanamycine. This suggests that the metal ion plays an important role in the antibacterial activities of complexes.
Golcu A, Tumer M, Demirelli H, Wheatley RA. Cd (II) and Cu (II) complexes of polydentate Schiff base ligands: Synthesis, characterization, properties and biological activity. Inorganica Chimica Acta. 2005; 358(6):1785-1797.
Justin DC, Sivasankaran NM. Synthesis, characterization and antimicrobial studies of some Schiff-base metal (II) complexes. Journal of Coordination Chemistry. 2009; 62(24):4018-4028.
Badwaik VB, Aswar AS. Synthesis, characterization and biological studies of some Schiff base complexes. Russian Journal of Coordination Chemistry. 2007; 33(10):755-760.
Keypour H, Shayesteh M, Rezaeivala M, Chalabian F, Elerman Y, Buyukgungor O. Synthesis, spectral characterization, structural investigation and antimicrobial studies of mononuclear Cu (II), Ni (II), Co (II), Zn (II) and Cd (II) complexes of a new potentially hexadentate N2O4 Schiff base ligand derived from salicylaldehyde. Journal of Molecular Structure. 2013;1032: 62-68.
Bhaskar R, Salunkhe N, Yaul A, Aswar A. Bivalent transition metal complexes of ONO donor hydrazone ligand: Synthesis, structural characterization and antimicrobial activity. Spectrochimica Acta Part A. 2015;151:621-627.
Mishra AP, Khare M, Gautam SK. Synthesis, physico-chemical characterization and antibacterial studies of some bioactive Schiff bases and their metal chelates. Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry. 2002;32(8):1485-1500.
Zafar H, Ahmad A, Khan AU, Khan TA. Synthesis, characterization and antimicrobial studies of Schiff base complexes. Journal of Molecular Structure. 2015;1097:129-135.
Neelakantan MA, Esakkiammal M, Mariappan SS, Dharmaraja J, Jeyakumar T. Synthesis, characterization and biocidal activities of some schiff base metal complexes. Indian Journal of Pharmaceutical Sciences. 2010;72(2):216.
Rajavel R, Vadivu MS, Anitha C. Synthesis, physical characterization and biological activity of some Schiff base complexes. Journal of Chemistry. 2008; 5(3):620-626.
Arish D, Sivasankaran Nair M. Synthesis, characterization, antimicrobial and nuclease activity studies of some metal Schiff-base complexes. Journal of Coordination Chemistry. 2010;63(9):1619-1628.
El-Behery M, El-Twigry H. Synthesis, magnetic, spectral, and antimicrobial studies of Cu (II), Ni (II) Co (II), Fe (III), and UO2 (II) complexes of a new Schiff base hydrazone derived from 7-chloro-4-hydrazinoquinoline. Spectrochimica Acta Part A. 2007;66(1):28-36.
Shiju C, Arish D, Bhuvanesh N, Kumaresan S. Synthesis, characterization, and biological evaluation of Schiff base–platinum (II) complexes. Spectrochimica Acta Part A. 2015;145:213-222.
Ganji N, Rambabu A, Vamsikrishna N, Daravath S. Copper (II) complexes with isoxazole Schiff bases: Synthesis, spectroscopic investigation, DNA binding and nuclease activities, antioxidant and antimicrobial studies. Journal of Molecular Structure. 2018;1173:173-182.
Kalita M, Bhattacharjee T, Gogoi P, Barman P, Kalita RD, Sarma B, Karmakar S. Synthesis, characterization, crystal structure and bioactivities of a new potential tridentate (ONS) Schiff base ligand N-[2-(benzylthio) phenyl] salicylaldimine and its Ni (II), Cu (II) and Co (II) complexes. Polyhedron. 2013;60: 47-53.
Singh K, Barwa MS, Tyagi P. Synthesis and characterization of cobalt (II), nickel (II), copper (II) and zinc (II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1, 2, 4-triazine. European Journal of Medicinal Chemistry. 2007;42(3):394-402.
Harinath Y, Reddy DH, Kumar BN, Apparao C, Seshaiah K. Synthesis, spectral characterization and antioxidant activity studies of a bidentate Schiff base, 5-methyl thiophene-2-carboxaldehyde-carbohydrazone and its Cd (II), Cu (II), Ni (II) and Zn (II) complexes. Spectrochimica Acta Part A. 2013;101:264-272.
Savithri K, Kumar BC, Vivek HK, Revanasiddappa HD. Synthesis and Characterization of Cobalt (III) and Copper (II) Complexes of 2-((E)-(6-Fluorobenzo [d] thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities. International Journal of Spectroscopy. 2018.
[Article ID: 8759372]
Saghatforoush LA, Chalabian F, Aminkhani A, Karimnezhad G, Ershad S. Synthesis, spectroscopic characterization and antibacterial activity of new cobalt (II) complexes of unsymmetrical tetradentate (OSN2) Schiff base ligands. European Journal of Medicinal Chemistry. 2009;44 (11):4490-4495.
Chakrabarty M, Ahmed A, Lal RA. Synthesis, characterization, and structural assessment of Ni (II) complexes derived from bis (2-hydroxy-1-naphthaldehyde) succinoyldihydrazone. International Journal of Inorganic Chemistry. 2015;
[Article ID: 121895]
Patil SA, Naik VH, Kulkarni AD, Badami PS. DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co (II), Ni (II) and Cu (II) complexes with SNO donor coumarin Schiff bases. Spectrochimica Acta Part A. 2010;75(1): 347-354.
Pervaiz M, Ahmad I, Yousaf M, Kirn S, Munawar A, Saeed Z, Adnan A, Gulzar T, Kamal T, Ahmad A, Rashid A. Synthesis, spectral and antimicrobial studies of amino acid derivative Schiff base metal (Co, Mn, Cu, and Cd) complexes. Spectrochimica Acta Part A. 2019;206: 642-649.
Rosu T, Pahontu E, Maxim C, Georgescu R, Stanica N, Gulea A. Some new Cu (II) complexes containing an on donor Schiff base: Synthesis, characterization and antibacterial activity. Polyhedron. 2011;30 (1):154-162.