Impact of Preferred Orientation and Strain on Olopetadine HCL by Using XRD Technique

Shivaji Jadhav *

Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.

Amit Jadkar

Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.

Namdev Mote

Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.

Shridhar Tamse

Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.

Amit Gosar

Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.

Dileep Mahajan

Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.

*Author to whom correspondence should be addressed.


Abstract

This research article investigates the impact on the crystal structure of Olopatadine HCl using an X-ray diffractometer. During the stability study, the diffractogram obtained shows a significant shift in 2ϴ, which can be attributed to the presence of strain and preferred orientation within the crystal lattice. The study reveals that the strain is caused by lattice defects and may be due to moisture, while the preferred orientation can be attributed to the method of preparation adopted. The results indicate that the crystal structure of Olopatadine HCl is complex and requires further investigation to fully understand its properties. The findings of this study could be used to optimise the synthesis protocol and improve the material properties for various applications.

Keywords: Preferred orientation, olopetadine HCl, XRD, IR


How to Cite

Jadhav , S., Jadkar , A., Mote , N., Tamse , S., Gosar , A., & Mahajan , D. (2023). Impact of Preferred Orientation and Strain on Olopetadine HCL by Using XRD Technique. Asian Journal of Applied Chemistry Research, 14(4), 17–22. https://doi.org/10.9734/ajacr/2023/v14i4273

Downloads

Download data is not yet available.

References

Tamura T, Sato H, Miki I, Suzuki K, Ohmori K, Karasawa A. Effects of orally administered olopatadine hydrochloride on the ocular allergic reaction in rats. Allergology; 2003.

Uchio Eiichi. Treatment of allergic conjunctivitis with olopatadine hydrochloride eye drops. Clinical Ophthalmology 2.3. 2008:525-531.

Eugene McLaurin, Mark Bergmann Abhijit Narvekar, Adeniyi Adewale, Paul Gomes, Gail Torkildsen. Pooled analysis of two studies evaluating efficacy and safety of olopatadine hydrochloride 0.77% in patients with allergic conjunctivitis. Clinical Ophthalmology 11, pages 1089-1097.International. 2017;52(2):77-83

Ohmori K, Hayashi KI, Kaise T, Ohshima E, Kobayashi S, Yamazaki T, Mukouyama A. Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. The Japanese Journal of Pharmacology, 2002;88(4):379-397.

Robinson Ian, Ross Harder. Coherent X-ray diffraction imaging of strain at the nanoscale. Nature materials 8.4. 2009:291-298.

Abramowitz R, Yalkowsky SH. Melting point, boiling point, and symmetry. Pharmaceutical research. 1990;7:942-947.

Brown Herbert C. Chemical effects of steric strains. Journal of the Chemical Society (Resumed).1956:1248-1268.

Nobre, Thatyane M. et al. Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models. Thin Solid Films. 2015;593:158-188.

Wiberg KB. The concept of strain in organic chemistry. Angewandte Chemie International Edition in English. 1986;25(4):312-322.

Bunjes, Heike, Tobias Unruh. Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering." Advanced drug delivery reviews. 2007;59(6):379-402.

York P. Crystal engineering and particle design for the powder compaction process. Drug Development and Industrial Pharmacy. 1992;18(6-7):677-721.

Bhatnagar Bakul, et al. Protein/ice interaction: high-resolution synchrotron X-ray diffraction differentiates pharmaceutical proteins from lysozyme." The Journal of Physical Chemistry B. 2019123(27):5690-5699.

Nasiri-Tabrizi, Bahman, Abbas Fahami, and Reza Ebrahimi-Kahrizsangi. "A comparative study of hydroxyapatite nanostructures produced under different milling conditions and thermal treatment of bovine bone. Journal of Industrial and Engineering Chemistry. 2014;20(1):245-258.