Impact of Preferred Orientation and Strain on Olopetadine HCL by Using XRD Technique
Shivaji Jadhav *
Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.
Amit Jadkar
Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.
Namdev Mote
Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.
Shridhar Tamse
Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.
Amit Gosar
Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.
Dileep Mahajan
Indoco Remedies Ltd., R&D Centre Rabale, Navi Mumbai -400701, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
This research article investigates the impact on the crystal structure of Olopatadine HCl using an X-ray diffractometer. During the stability study, the diffractogram obtained shows a significant shift in 2ϴ, which can be attributed to the presence of strain and preferred orientation within the crystal lattice. The study reveals that the strain is caused by lattice defects and may be due to moisture, while the preferred orientation can be attributed to the method of preparation adopted. The results indicate that the crystal structure of Olopatadine HCl is complex and requires further investigation to fully understand its properties. The findings of this study could be used to optimise the synthesis protocol and improve the material properties for various applications.
Keywords: Preferred orientation, olopetadine HCl, XRD, IR