Asian Journal of Applied Chemistry Research http://journalajacr.com/index.php/AJACR <p style="text-align: justify;"><strong>Asian Journal of Applied Chemistry Research (ISSN: 2582-0273)</strong>&nbsp;aims to publish high-quality papers (<a href="/index.php/AJACR/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of 'chemistry and its application'. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US contact@journalajacr.com (Asian Journal of Applied Chemistry Research) contact@journalajacr.com (Asian Journal of Applied Chemistry Research) Fri, 16 Aug 2019 11:29:22 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Extraction and Characterization of Oil from Date Palm (Phoenix dactylifera) Seed http://journalajacr.com/index.php/AJACR/article/view/30095 <p>This work focuses on the extraction of oil from date palm seed. Using n-hexane in Soxlet extraction apparatus, standard procedures were followed to determine the oil feed stock yield. Proximate compositions and physicochemical characteristics were carried out. Also, Fourier Transform Infrared Spectroscopy (FTIR) and Gas Chromatography Mass Spectrometry (GC-MS) were used to determine the functional groups and the fatty acid composition of the oil respectively. The result shows that the appearance of date palm seed oil is reddish brown in colour. Result from the FTIR analysis also shows that 17 peaks were noticed from date palm seed oil, indicating the presence of various functional groups such as OH, C-H, C=C, C=O, C &nbsp;The dominating types and number of functional groups are found on the single bond stretch and on the fingerprint region skeletal vibration. Similarly, the GC-MS result also reveals that there are 5 dominating fatty acid compounds present in date palm seed oil in relation to their abundant relative weight composition. In date seed oil, oleic acid which comprise of omega-9 fatty acid is found to be the only monounsaturated fatty acid with the highest weight composition of 49.4%. The inference that can be drawn from the results in this work in relation to application suggest that, date palm seed oil will be suitable for soap production and cleansing agents. Also, omega-9 fatty acid has some health benefits that can strengthen the brain as well as the heart. Furthermore, research on the life shelf and storage of this oil should be looked into, as it relates to the peroxidation of oil.</p> J. A. Olowokere, A. I. Onen, M. C. Odineze, I. D. B’aga, E. G. Kefas ##submission.copyrightStatement## http://journalajacr.com/index.php/AJACR/article/view/30095 Fri, 16 Aug 2019 00:00:00 +0000 Validated Stability – Indicating Methods for Determination of Sofosbuvir by UPLC and HPTLC in Pure Form and Tablet Dosage Forms http://journalajacr.com/index.php/AJACR/article/view/30097 <p><strong>Aims: </strong>Two simple and sensitive stability- indicating methods were developed and validated for the quantitative determination of sofosbuvir in presence of its degradation products.</p> <p><strong>Study Design:</strong> Ultra high performance liquid chromatography (UPLC), High performance thin layer chromatography (HPTLC) are developed for determination of sofosbuvir in presence of its degradation products, laboratory-prepared mixtures and in tablet dosage forms.</p> <p><strong>Place and Duration of Study:</strong> Analytical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, between August 2018 and March 2019.</p> <p><strong>Methodology: </strong>Two simple and sensitive stability- indicating methods were developed and validated for the quantitative determination of Sofosbuvir in presence of its degradation products. The first method was an Ultra Performance Liquid Chromatography (UPLC) method, in which efficient separation was carried out on phenomenex kinetex 2.6 μm C18 100 A column using a mobile phase consisting of filtered and degassed mixture of 0.1% ortho-phosphoric acid in water and methanol with the ratio of (40:60% v/v) adjusted to pH 3.5, at a flow rate of 1 mL min<sup>-1</sup> and UV detection at 260 nm at ambient temperature. The second method is a high performance- thin layer chromatographic one (HPTLC) in which chromatographic separation was performed on silica gel 60 F<sub>254</sub> plates, with methanol – chloroform – ammonia (2.5: 6: 1.5 % v/v/v) as a developing system followed by densitometric determination at 261 nm. Sofosbuvir was subjected to stress conditions including alkaline, acidic and oxidative degradation.</p> <p><strong>Results: </strong>Beer’s law was obeyed over the range of 1-20 μg mL<sup>–1</sup> for UPLC and 2-12 μg / spot for HPTC with good accuracy and precision using the two procedures, respectively. Results obtained was statistically analysed and found to be in accordance with those given by the reported method.</p> <p><strong>Conclusion:</strong> The proposed methods were successfully applied for the determination of sofosbuvir in bulk powder, laboratory prepared mixtures and pharmaceutical dosage form with good accuracy and precision. The methods were validated according to ICH guidelines. The results obtained were compared with those of the reported method and were found to be in good agreement.</p> Sawsan A. Abdel-Razeq, Zeinab Adel Nasr, Noha S. Said ##submission.copyrightStatement## http://journalajacr.com/index.php/AJACR/article/view/30097 Tue, 20 Aug 2019 00:00:00 +0000