Synthesis, Characterization, Antibacterial and Thermal Studies of Cu(II) Complex of Thiophene-2- aldehyde Semicarbazone

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Dipta Sarker
Md. Yeamin Reza
Md. Masuqul Haque
Rausan Zamir
Md. Ali Asraf


Copper (II) complex of the ligand, thiophene-2-aldehyde semicarbazone was synthesized and characterized. Their structures were explored on the basis of CHN analysis, conductance and magnetic susceptibility measurements, spectral studies (FT-infrared and ESI-MS) and thermogravimetric analysis (TGA). It has been observed from spectral and analytical studies, the copper complex have the composition of [CuL(CH3COO)2(H2O)] [where L is thiophene-2-aldehyde semicarbazone]. The electrospray mass spectrum of the ligand and complex exhibited ion at mass-to charge ratio (m/z) of 169.13 and 368.86 matching the calculated values for the molecular ion of the ligand and complex, respectively. One mole of the ligand behaves as bidentate chelating agents around the Cu(II) ion. From conductivity studies, we obtained that the copper complex of the ligand, thiophene-2-aldehyde semicarbazone had no ionic properties. All data confirmed a trigonal bipyramidal geometry of the complex. Antibacterial activity of the compounds against the microbe Enterobacter aerogenes and Bacillus cereus have been screened to reflect that the complex has higher antimicrobial activity than the free ligand.

Schiff base, bidentate ligand, complexation, thermal analysis, antibacterial activity.

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Sarker, D., Reza, M. Y., Haque, M. M., Zamir, R., & Asraf, M. A. (2020). Synthesis, Characterization, Antibacterial and Thermal Studies of Cu(II) Complex of Thiophene-2- aldehyde Semicarbazone. Asian Journal of Applied Chemistry Research, 4(4), 1-10.
Original Research Article


Islam MA, Karim MR, Zahan MK-E. Studies on synthesis, characterization and biological activity of Mn(II), Cu(II), Fe(II) and Al(III) metal complexes of schiff base ligand derived from semicarbazide and anisaldehyde. M. Sc. (Thesis), Dept. of Chemistry, Rajshahi University, Bangladesh; 2017.

Koh L, et al. Complexes of salicylaldehyde acylhydrazones: cytotoxicity, QSAR and crystal structure of the sterically hindered t-butyl dimer. Journal of Inorganic Biochemistry. 1998;72(3-4):155-162.

Ainscough EW, et al. Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: Quantitative structure–activity elationships. Journal of Inorganic Biochemistry. 1999; 77(3-4):125-133.

Djebbar-Sid S, Benali-Baitich O, Deloume J. Synthesis, characterization and electrochemical behaviour of some copper (II) complexes with linear and tripodal tetradentate ligands derived from Schiff bases. Polyhedron. 1997;16(13):2175 2182.

Ross A, Slawin AZ. First synthesis of a unique dilead Schiff base complex. Journal of the Chemical Society, Dalton Transactions. 1998;19:3149-3150.

He L, et al. The formation of a Schiff base intermediate: a nickel (II) complex of an asymmetric tripodal ligand. Journal of Chemical Crystallography. 1999;29(2):207-210.

Wu JC, et al. Intramolecular hydrogen bond self-template synthesis of some new Robson-type macrocyclic ligands. Chinese Chemical Letters; 2001.

Asraf MA. et al. Structural Elucidation, 3D Molecular Modeling and Antibacterial Activity of Ni (II), Co (II), Cu (II) and Mn (II) Complexes Containing Salophen Ligand. Asian Journal of Applied Chemistry Research. 2019;1-15.

Sarker D, et al. Copper (II) Complex of Salicylaldehyde Semicarbazone: Synthesis, Characterization and Antibacterial Activity. Asian Journal of Chemical Sciences. 2019;1-8.

Al-Allaf TA, Sheet AZ. Platinum group metal Schiff base complexes—I. Platinum complexes. Polyhedron. 1995;14(2):239 248.

Highfield JA, et al. Synthesis, hydroxyl radical production and cytotoxicity of analogues of bleomycin. Bioorganic & Medicinal Chemistry. 2000;8(5):1065-1073.

Das A, et al. Inhibition of herpes simplex virus type 1 and adenovirus type 5 by heterocyclic Schiff bases of aminohydroxyguanidine tosylate. Antiviral Research. 1999;44(3):201-208.

Djebbar-Sid S, Benali-Baitich O, Deloume JP. Synthesis, characterization, electrochemical behaviour and catalytic activity of manganese (II) complexes with linear and tripodal tetradentate ligands derived from Schiff bases. Transition Metal Chemistry. 1998;23(4):443-447.

Asraf MA, et al. Earth-abundant metal complexes as catalysts for water oxidation; Is it homogeneous or heterogeneous? Catalysis Science & Technology. 2015; 5(11):4901-4925.

Asraf MA, et al. Homogeneous photochemical water oxidation with metal salophen complexes in neutral media. Photochemical & Photobiological Sciences; 2019.

Asraf MA, et al. Homogeneous photochemical water oxidation with metal salophen complexes in neutral media. Photochemical & Photobiological Sciences. 2019;18(11):2782-2791.

Hamada Y. The development of chelate metal complexes as an organic electroluminescent material. IEEE Transactions on Electron Devices. 1997; 44(8):1208-1217.

Patel P, Thaker B, Zele S. Preparation and characterisation of some lanthanide complexes involving a heterocyclic β–diketone. Indian Journal of Chemistry. 1999;38A:563-567.

Mohammed AA. Synthesis and spectroscopic studies of some furfuraldehyde schiff bases complexes. Iraqi National Journal of Chemistry. 2005; 17:103-111.

Rollas S, Küçükgüzel SG. Biological activities of hydrazone derivatives. Molecules. 2007;12(8):1910-1939.

Aurbach D, et al. Design of electrolyte solutions for Li and Li-ion batteries: A review. Electrochimica Acta. 2004; 50(23):247-254.

Bottari B, et al. Isoniazid-related copper (II) and nickel (II) complexes with antimycobacterial in vitro activity. Part 9. Bioorganic & Medicinal Chemistry Letters. 2000;10(7):657-660.

Sridhar SK, Saravanan M, Ramesh A. Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives. European Journal of Medicinal Chemistry. 2001;36(7-8):615-625.

Kaymakçıoğlu BK, Rollas S. Synthesis, characterization and evaluation of antituberculosis activity of some hydrazones. Il Farmaco. 2002;57(7):595-599.

Agarwal RK, Singh L, Sharma DK. Synthesis, spectral, and biological properties of copper (II) complexes of thiosemicarbazones of Schiff bases derived from 4-aminoantipyrine and aromatic aldehydes. Bioinorganic Chemistry and Applications; 2006.

Singh N, et al. Antitumor activity studies of newly synthesized N-salicyloyl-N′-(p-hydroxybenzthioyl) hydrazine and its copper (II) complex both in vivo and in vitro. Bioorganic & Medicinal Chemistry. 1997;5(2):245-251.

Agarwala B, Hingorani S, Gowda GN. Synthetic and physicochemical studies of uranium complexes with semicarbazone and hydrazone. Inorganica Chimica Acta. 1990;176(1):149-154.

Singh NK, et al. Synthesis, characterization and antitumour studies on N-salicyl-N′-thiobenzohydrazide and its copper (II) complex. Transition Metal Chemistry. 1996;21(6):556-559.

Maurya R, Verma R, Singh T. Synthesis, magnetic, and spectral studies of some mono‐and binuclear dioxomolybdenum (vi) complexes with chelating hydrazones derived from acid hydrazides and furfural or thiophene‐2‐aldehyde. Synthesis and Reactivity in Inorganic and Metal-organic Chemistry. 2003;33(2):309-325.

Raoot K, Raoot S, Vaidya V. A selective complexometric determination of palladium. Indian Journal of Chemistry. 1979;18A:90.

Drew WL, et al. Reliability of the Kirby-Bauer disc diffusion method for detecting methicillin-resistant strains of Staphylococcus aureus. Appl. Environ. Microbiol. 1972; 24(2):240-247.

Raman N, et al. Synthesis, structural characterisation and electrochemical and antibacterial studies of Schiff base copper complexes. Transition Metal Chemistry. 2004;29(2):129-135.

Osman AH. Synthesis and characterization of cobalt (II) and nickel (II) complexes of some Schiff bases derived from 3-hydrazino-6-methyl [1, 2, 4] triazin-5 (4H) one. Transition Metal Chemistry. 2006; 31(1):35-41.

Ahmed A, BenGuzzi S, El-Hadi A. Synthesis and characterization of divalent transition metals complexes of Schiff bases derived from O-Phenylenediamine and Benzoylacetone and Related species. Journal of Science and Its Applications. 2007;1(1):79-90.

Payne K, Veis A. Fourier transform IR spectroscopy of collagen and gelatin solutions: deconvolution of the amide I band for conformational studies. Biopolymers: Original Research on Biomolecules. 1988;27(11):1749-1760.

Jellouli NK, et al. Founder effect confirmation of c. 241A> G mutation in the L2HGDH gene and characterization of oxidative stress parameters in six Tunisian families with L-2-hydroxyglutaric aciduria. Journal of Human Genetics. 2014;59(4): 216.

Vogt RL, Dippold L. Escherichia coli O157: H7 outbreak associated with consumption of ground beef, June–July 2002. Public Health Reports. 2005;120(2):174-178.

Ejidike I, Ajibade P. Synthesis, characterization and biological studies of metal (II) complexes of (3E)-3-[(2-{(E)-[1-(2, 4-dihydroxyphenyl) ethylidene] amino} ethyl) imino]-1-phenylbutan-1-one Schiff base. Molecules. 2015;20(6):9788-9802.

Aziz AAA, et al. Synthesis, structural characterization, thermal studies, catalytic efficiency and antimicrobial activity of some M (II) complexes with ONO tridentate Schiff base N-salicylidene-o-aminophenol (saphH2). Journal of Molecular Structure. 2012;10(10):130- 138.