Biophysical Study for the Interactions of Some Diazo Dyes with Human Serum Albumin

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Mohammed Hadi Al–Douh
Elham Abdalrahem Bin Selim
Edrees Muhammad Tahir
Sabah Ahmed Abdo Esmail
Yaman Ahmed Naji
Hassan Hadi Abdullah


The biophysical interactions between the human serum albumin HSA and three synthesized diazo dyes 1-3 have been investigated by thermodynamic parameters and molecular docking technique. The binding constants Kb were calculated and the compounds were ranked according to their docking free energy. Different interactions were elucidated at the active site of the protein. Among these interactions is the hydrogen bonding which plays an essential role in the interaction with the protein. Both the theoretical and practical studies have agreed that diazo dye 1 has the strongest interaction with the active site.

Molecular docking, diazo dyes, nitro functional group, human serum albumin HSA, thermodynamic parameters, hydrogen bonding.

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How to Cite
Hadi Al–Douh, M., Abdalrahem Bin Selim, E., Muhammad Tahir, E., Ahmed Abdo Esmail, S., Ahmed Naji, Y., & Hadi Abdullah, H. (2019). Biophysical Study for the Interactions of Some Diazo Dyes with Human Serum Albumin. Asian Journal of Applied Chemistry Research, 4(3), 1-10.
Original Research Article


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